Six patients in the FF/VI (2%) and three in the FP/SAL (1%) arm experienced serious adverse events, none of which were considered to be drug related. Improvements in lung function and health status were not significantly different between FF/VI 100/25 μg once daily and FP/SAL 500/50 μg twice daily; there was no apparent …Russia targeted Ukraine’s power facilities in the winter of 2022 and 2023, plunging parts of Kyiv and other cities into cold and darkness, sometimes for hours or …『ファイナルファンタジー』第6作。これまでの象徴であった“クリスタル”を廃し、魔法が滅んだ世界を舞台とする。ハードの限界を超えたドット表現、群像劇のように次々と変わっていく主人公。それぞれの物語が交差し、やがてひとつのカタストロフィーを迎える。Running, squatting, and other exercises are better for your knees than just sitting around. It is 2022, and there are still people out there saying that exercises like running or s...Jul 20, 2023 ... Hi Guys *** We will be giving away a game of choice to one lucky subscriber once we reach 2500 subscribers :-) Happy gaming guys *** Welcome ...Aug 22, 2022 · Final Fantasy VI originally released in 1994 for the SNES and still holds up as the best game in the series to this day. Final Fantasy VII is largely regarded as the best entry in the series and for good reason. It was the first installment to feature polygonal graphics, and it included many smart gameplay additions such as the Materia system ...Sep 9, 2020 · The approved FF/UMEC/VI indication for both COPD and asthma is 100/62.5/25 mcg, with an additional strength dosage of 200/62.5/25 mcg for asthma alone. According to GSK, the indication for maintenance treatment of asthma in adult patients associates with about 30% of eligible patients who still experience symptoms despite adherence to inhaled ...There are a lot of good reasons to take food tours while traveling abroad and in this article, we’ll show you some of them. Sharing is caring! While traveling abroad, the first thi...Introduction: FF and VI are, respectively, a novel inhaled corticosteroid and long-acting beta2 agonist in development as a combined OD therapy for asthma and COPD. Objectives: To compare the efficacy and safety of FF/VI with FF and fluticasone propionate (FP) in patients (≥12 years old; on ICS) with moderate-to-severe persistent asthma.The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to compare the efficacy of FF/VI with fluticasone propionate (FP)/salmeterol (SAL) in patients with persistent asthma …May 6, 2021 · As you can see, that's in a way different from setting ff=unix but it has a very similar effect. Also, enabling 'binary' has other side effects during editing, for instance to options such as 'textwidth' and 'expandtab' , but perhaps that's acceptable (or even desirable) to you in this case.The effect of single-inhaler FF/UMEC/VI versus single-inhaler FF/VI or UMEC/VI in COPD on changes in SGRQ total score has also been a secondary outcome of the IMPACT trial. Citation 40 In this study, the patients with triple therapy presented an improvement in mean change from baseline in the SGRQ total score when compared with the FF/VI and ...Dec 2, 2021 · bash 执行 vim 命令 + vim 命令拼接 +批量执行set ff=unix （亲测有效） - 小黑狐狸1001 - 博客园. 会员.Jul 4, 2019 · Reversible is defined as an increase in FEV1 of at least 12% and at least 200 mL after administration of salbutamol. Not reversible is an increase in FEV1 of less than 200 mL or an increase of 200 mL or more that is less than 12% of the pre-salbutamol FEV1. FF/UMEC/VI n=4136; UMEC/VI n=2063; FF/VI n=4124; total n=10 323.Oct 10, 2019 · set ff=unix : 告诉 vi 编辑器，使用unix 换行符。 操作步骤： 1.用vi命令打开文件 2.直接输入 ：set ff=unix posted @ 2019-10-10 14:56 coolw 阅读(18291) 评论(0) 编辑 收藏 举报 会员力量，点亮园子希望 ...Final Fantasy VI Pixel Remaster is the ultimate edition of one of the most beloved RPGs of all time. Whether you are a veteran or a newcomer, you will appreciate this detailed walkthrough guide that covers everything from the story, the characters, the combat, the magic, the espers, the items, and the trophies. Don't miss this chance to experience the epic saga of Terra, Locke, …Mar 21, 2022 ... Get ready for the FINAL FANTASY VI collaboration starting 3/23/2022! Terra, Locke, and Celes will all be joining the fray as collaborative ...Visits to the toy store were a lot different for Jim Clayton since he took the job as president of Playto Industries. Long lines at the checkout counter used to infuriate him. Now ...下载 Firefox 上的 Vimium。The Hacker's Browser. Vimium provides keyboard shortcuts for navigation and control in the spirit of Vim. Keyboard Bindings Modifier keys are specified as <c-x>, <m-x>, and <a-x> …Take advantage of the summer blooms in your garden by making this attractive mossy flower vase! This easy DIY project makes a great gift and is a perfect way to display everything ...Sep 9, 2020 · The approved FF/UMEC/VI indication for both COPD and asthma is 100/62.5/25 mcg, with an additional strength dosage of 200/62.5/25 mcg for asthma alone. According to GSK, the indication for maintenance treatment of asthma in adult patients associates with about 30% of eligible patients who still experience symptoms despite adherence to inhaled ...Jul 17, 2022 · FF/UMEC/VI also demonstrated improvements in mean SGRQ score versus other triple therapy comparators at 24 weeks, and a significant reduction in RMU compared with BUD/GLY/FOR (160/18/9.6). The findings of this NMA suggest favorable efficacy with single-inhaler triple therapy comprising FF/UMEC/VI. Further analysis is required as …May 6, 2021 · As you can see, that's in a way different from setting ff=unix but it has a very similar effect. Also, enabling 'binary' has other side effects during editing, for instance to options such as 'textwidth' and 'expandtab' , but perhaps that's acceptable (or even desirable) to you in this case.Il faut dire qu'elle possède une particularité : elle est née avec le don de la magie, alors que celle-ci est censée avoir disparu depuis un millénaire. Sa ... Concept and design. Final Fantasy VI was the first game of the series to feature character designers other than Yoshitaka Amano.While Amano drew most character artwork, monster designer and graphic director Tetsuya Nomura created the original designs and many story episodes for Shadow and Setzer Gabbiani, and field graphic designer Kaori Tanaka created the original designs of Edgar Roni Figaro ... Conclusions: FF/UMEC/VI reduced the rate of mod/sev exac in patients with symptomatic COPD at risk of exac, compared with FF/VI or UMEC/VI, irrespective of age, exacerbation history and CV risk subgroup. Footnotes Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA4383. This is an ERS International Congress abstract.Feb 15, 2024 · About this game. A remodeled 2D take on the sixth game in the world-renowned FINAL FANTASY series! Enjoy the timeless story told through charming retro graphics. All the magic of the original,... Final Fantasy VI: Directed by Hiroyuki Itô, Yoshinori Kitase. A mysterious woman joins a group of mercenaries in order to find out about her destiny and means of saving the world from an evil madman.Jul 10, 2021 ... Writer and musician Sebastian Deken explores legendary composer Nobuo Uematsu's incredible score for Square Enix's iconic "Final Fantasy VI.Final Fantasy VI (originally released in the US as Final Fantasy III for the SNES) is Square's sixth installment in the Final Fantasy series. Considered by many to …4 days ago · In the above, replacing :set ff=unix with :set ff=mac would write the file with mac (CR-only) line endings. Or, if it was a mac file to start with, you would use :e ++ff=mac to read the file correctly, so you could convert the line endings to unix or dos.. Convert from dos/unix to dos. To convert the current file from any mixture of …Oct 24, 2022 · Patients and methods . IMPACT was a 52-week, randomized, double-blind, multicenter study comparing FF/UMEC/VI 100/62.5/25 µg with FF/VI 100/25 µg or UMEC/VI 62.5/25 µg in patients ≥40 years with symptomatic COPD and ≥1 moderate/severe exacerbation in the previous year.6 days ago ... In this video, I showcase part 2 of my first time playing Final Fantasy VI Pixel Remaster! I Hope you enjoy my playthrough!4 days ago · Switches defense with WallChange, so use Flare and Ultima. He'll use his own Ultima at the end, so have at least one person ready with Life 3. Dies at 0 MP. The Magic Master is a boss in Final Fantasy VI fought at the top of the Cultists' Tower as the party reaches the Soul of Thamasa treasure. The Cult of Kefka, apparently having deduced … The original FINAL FANTASY VI comes to life with completely new graphics and audio as a 2D pixel remaster! A remodeled 2D take on the sixth game in the world-renowned FINAL FANTASY series! Enjoy ... Aug 1, 2018 · The efficacy of FF/VI was demonstrated in patients with stable but unsatisfactorily controlled asthma (with an ACT total score of ≥15 to <20). FF/VI once daily was shown to be non-inferior to usual ICS/LABA twice daily with regards to improving asthma control over 24 weeks of treatment.Oct 29, 2020 · Patients and methods: IMPACT was a 52-week, randomized, double-blind, multicenter study comparing FF/UMEC/VI 100/62.5/25 µg with FF/VI 100/25 µg or UMEC/VI 62.5/25 µg in patients ≥40 years ...Nov 1, 2023 · This study assessed the impact of FF/UMEC/VI on OCS use among patients with COPD previously treated with OCS. Patients and methods: A retrospective database study of patients with COPD aged ≥40 years who initiated FF/UMEC/VI from 1 November 2017 to 31 December 2018, identified through the MarketScan ® Commercial and …The time horizon and treatment duration were 3 years (base case). One-way sensitivity, scenario, and probabilistic sensitivity analyses were performed.Results: FF/UMEC/VI treatment resulted in fewer exacerbations over 3 years (4.130 vs 3.648) versus FF/VI, with a mean (95% confidence interval [CI]) incremental cost of € 444 (€ 149, € 713 ...Chromium(VI) phosphate has the chemical formula Cr(PO4)2 because it contains one chromium ion bonded to two phosphate ions. The phosphate ions each have a charge of negative 3, whi...Oct 6, 2014 · Go downstairs and speak to the little boy; Locke will have to choose one of three phrases to tell him: “Rosebud,” “Courage,” or “Failure.”. Pick “Courage” and the kid will open up ... Jun 5, 2023 · Final Fantasy VI (originally released in the US as Final Fantasy III for the SNES) is Square's sixth installment in the Final Fantasy series. Considered by many to be the best of the series, FFVI is well known for its great story and character development, as well as its unique (for its time) open-world experience. *This remaster is based on the original "FINAL FANTASY VI" game released in 1994. Features and/or content may differ from previously rereleased versions of the game. *This version of the game has not had the BGM and font selection functionality available on on some platforms added. [Applicable Devices] Devices equipped with Android 6.0 or higher 6 days ago ... In this video, I showcase part 2 of my first time playing Final Fantasy VI Pixel Remaster! I Hope you enjoy my playthrough!Mar 21, 2022 ... Get ready for the FINAL FANTASY VI collaboration starting 3/23/2022! Terra, Locke, and Celes will all be joining the fray as collaborative ...May 15, 2023 · Yet FINAL FANTASY VI has it all, and more. In its quest to learn and grow from every FINAL FANTASY before it, the developers didn’t just make a world worth exploring and experiencing, they made a world worth saving. All six games in the FINAL FANTASY pixel remaster series are now available to buy digitally on PS4 and Nintendo Switch. Jan 14, 2024 · Ryden, the 16-year-old inventive genius, releases a robotic spider that limits enemy movement and inflicts damage over time. Free Fire MAX is designed exclusively to deliver premium gameplay experience in a Battle Royale. Enjoy a variety of exciting game modes with all Free Fire players via exclusive Firelink …Jul 17, 2022 · FF/UMEC/VI also demonstrated improvements in mean SGRQ score versus other triple therapy comparators at 24 weeks, and a significant reduction in RMU compared with BUD/GLY/FOR (160/18/9.6). The findings of this NMA suggest favorable efficacy with single-inhaler triple therapy comprising FF/UMEC/VI. Further analysis is required as …Apr 2, 2019 · Final Fantasy VI was the last entry of the era, and April 2 marks the 25-year anniversary of its original Japanese launch date. Though Final Fantasy VI (initially called Final Fantasy III in North America) is an important part of gaming history, its venerable age means that some of today’s gamers haven’t played it for themselves. Study 200812 was a 24-week, non-inferiority study (N=1 055) that compared Trelegy Ellipta (92/55/22 micrograms) with FF/VI (92/22 micrograms) + UMEC (55 micrograms), co-administered once daily as a multi-inhaler therapy in patients with a history of moderate or severe exacerbations within the prior 12 months. FINAL FANTASY VI is a classic role-playing game that follows the resistance movement of the Returners against the Gestahlian Empire, a regime that aims to use magic for war and conquest. The game features a rich story, a diverse cast of characters, and a remastered version for modern platforms. Interplanetary communication will be a challenge. How will we keep in touch with other worlds? Here are 10 ideas for interplanetary communication. Advertisement Here on Earth, we'v...Running, squatting, and other exercises are better for your knees than just sitting around. It is 2022, and there are still people out there saying that exercises like running or s...1.1: Prelude: The Attack on Narshe. Escape through the M…. Narshe, a coal mining city that manages its own business and cares not for the war that is waged far away, has stumbled upon a mysterious find in their mines. The Empire, the all-consuming power-hungry nation to the far south of the world, has learned of this.Mar 1, 2022 ... ... Final Fantasy but this is the game that brought me into the franchise. This is Final Fantasy VI. Final Fantasy VI was released on April 2nd ...Whenever TV and movies portray a person with mental illness, it’s usually a “crazy schizophrenic,” an ax-wielding sociopath, a violent, drug-addicted mental patient or an Whenever ...Learn how to play FFVI, the sixth installment in the Final Fantasy series, on SNES and PSX platforms. Find tips, tricks, controls, and more in this comprehensive …Jan 1, 2021 · Compared to FF/VI, FF/UMEC/VI also improved symptoms and asthma control in a dose-related manner, with more patients showing clinically meaningful responses via ACQ scores. Dose-related numerical reductions in the annualised rate of moderate and/or severe exacerbations were observed in patients given …Final Fantasy VI is a game in the Final Fantasy series. At the time, three of the five preceding games in the series had not been released in the US, so it was released in …3 days ago · Aisha - Arvis - Baram - Chancellor - Crimson Robbers - Dancing Girl - Darill - Dream Stooges - Duane and Katarin - Duncan Harcourt - Elayne and Owain - Elder of Narshe - Gau's father - Gungho - Impresario - Interceptor - Kappa - Lola - Lone Wolf - Madeline - Maria - Mayor of Thamasa - Owzer - Queen - Rachel - …Jul 17, 2022 · FF/UMEC/VI also demonstrated improvements in mean SGRQ score versus other triple therapy comparators at 24 weeks, and a significant reduction in RMU compared with BUD/GLY/FOR (160/18/9.6). The findings of this NMA suggest favorable efficacy with single-inhaler triple therapy comprising FF/UMEC/VI. Further analysis is required as …Les avis des joueurs ... Final Fantasy VI est un chef d'oeuvre magistral! Le scénario du jeu est épique, émouvant, mélancolique, les scènes culte... ... Sixième ...Sep 20, 2017 · The incidences of the most frequent serious adverse events were worsening of COPD: 11%, 11% and 13% for FF/UMEC/VI, FF/VI and UMEC/VI, respectively; and pneumonia: 4%, 4% and 3% for FF/UMEC/VI, FF/VI and UMEC/VI, respectively. Patrick Vallance, President R&D, GSK, said: “We are delighted with the positive results achieved in the IMPACT study.Dec 16, 2022 · For FF/VI, these costs were partly offset by lower non-drug costs with FF/UMEC/VI, owing to fewer exacerbations and associated hospital stays and less time spent in the more costly state with poorer lung function, leading to a relatively small incremental cost of €444 per patient over 3 years. Savings in non-drug costs with …The inhaled corticosteroid fluticasone furoate (FF) and the long-acting β₂ agonist vilanterol (VI) are in development as a combined once-daily therapy for asthma and chronic obstructive pulmonary disease. Our study objectives were to compare the efficacy and safety of once-daily FF/VI with FF alone and twice-daily fluticasone propionate (FP ...Update: Some offers mentioned below are no longer available. View the current offers here. I finally made it to Israel, a destination I’ve been wanting to vi... Update: Some offers...2 days ago · Overview []. Announced on June 13, 2021 as part of Square Enix Presents Summer Showcase for E3 2021 and published on iOS, Android, Fire OS, and Microsoft Windows via Steam between July 2021 and February 2022, the Pixel Remaster series was promoted as being the "ultimate 2D remasters" of their respective games.. The spritework appears to be partially …The first step to setting up the iHome clock is selecting and adjusting the time zone. Press and hold the Time Zone button until the display begins to flash. Then, press the Select... Game description. Relm Arrowny is a playable character in Final Fantasy VI. She is a young but talented artist from Thamasa and Strago's adopted granddaughter. As a descendant of the Magi, Relm can naturally channel magic, which she does through her ability to Sketch monsters and bring them to life. The time horizon and treatment duration were 3 years (base case). One-way sensitivity, scenario, and probabilistic sensitivity analyses were performed.Results: FF/UMEC/VI treatment resulted in fewer exacerbations over 3 years (4.130 vs 3.648) versus FF/VI, with a mean (95% confidence interval [CI]) incremental cost of € 444 (€ 149, € 713 ...Final Fantasy 6 Walkthrough Sections. advertisement. World of Balance. Narshe. Figaro Castle. South Figaro Castle. Mt. Kolts. The Returners' Hideout. Lethe …Dec 7, 2020 · To convert file.txt from DOS to UNIX, open the file with Vim: vim file.txt. Set fileformat to unix: :set fileformat= unix. Save and quit the file: :wq. This is the same as running the command: vim '+set ff=unix' '+x' file.txt.Apr 13, 2018 · The primary comparison of FF/VI versus FP/SAL used a non-inferiority limit of −100 mL and a 0.025 one-sided significance level, with equal importance for the intent-to-treat (ITT) and per protocol (PP) populations. The inequality comparison of FF/VI versus FP assumed a true population effect of 100 mL and used a two-sided 5% significance ...Jan 4, 2016 · PEI-grafted Sepharose FF resin with IC = 740 mmol/L (FF-PEI-L740) was fabricated following the method described in Part I of this serial work [8], then the FF-PEI-L740 resin was modified with NaAc to neutralization of amine groups on the PEI chains for charge reduction according to the method described by Nakajima …There are 24 soldiers in the Imperial Palace, and you get one point for each one you talk to. Four of those soldiers will attack you when spoken to. Defeating them earns you 5 points apiece, for a maximum total of 44 points. If you want to get every possible reward, you can't afford to miss more than 3 points, so you'll need a strategy.Nov 2, 1994 · Summary. Originally released as Final Fantasy III in the US, Final Fantasy VI is one of the most engrossing RPGs of its era, letting players take control of an ever-expanding part of heroes on ... Jan 25, 2024 · Citation 7 FF/UMEC/VI has been shown to reduce exacerbations and improve lung function and health status compared with dual therapy. Citation 8 In addition, the cost-effectiveness of FF/UMEC/VI versus dual therapy and multiple-inhaler triple therapy (MITT) among patients with COPD has previously been demonstrated. Citation 9–13May 15, 2023 · Yet FINAL FANTASY VI has it all, and more. In its quest to learn and grow from every FINAL FANTASY before it, the developers didn’t just make a world worth exploring and experiencing, they made a world worth saving. All six games in the FINAL FANTASY pixel remaster series are now available to buy digitally on PS4 and Nintendo Switch. Aim: Study HZA106837 demonstrated a reduced risk of asthma exacerbations with FF/VI vs FF, measured by time-to-first severe asthma exacerbation over a ≥24–78 week treatment period (Bateman et al; Thorax 2014). This post-hoc analysis investigated whether asthma exacerbation prevalence varied across seasons. Methods: Patients aged ≥12 years with asthma for ≥1 year, …Jun 23, 2023 ... Tap to unmute. Your browser can't play this video. Learn more · @NyheterFantasy. Subscribe. Final Fantasy 6 REMAKE!!!! 1.2K. Dislike. 186.Jun 5, 2023 · Celes is basically Terra with slightly different stats, different natural Magic, and Runic in place of Trance. Other than this she functions very similarly to Terra, and, because of this, end-game she's another contender for a top-tier character. However, Celes is slightly inferior to Terra, since Runic is inferior overall to Trance, the Magic ... Aug 2, 2012 ... Final Fantasy VI: The Interactive CG Game, also known as the Final Fantasy SGI demo, was a short demonstration produced by Square using ...Interplanetary communication will be a challenge. How will we keep in touch with other worlds? Here are 10 ideas for interplanetary communication. Advertisement Here on Earth, we'v...
Oct 25, 2022 · Hence, FF/UMEC/VI was the dominant treatment option. The model suggested that patients receiving FF/UMEC/VI would have a numerically lower exacerbation rate compared with those receiving MITT over a lifetime, but the difference between the two treatment groups was extremely small (−0.063).. City making games
Jan 1, 2021 · Results from this study suggest that adding a second long-acting bronchodilator, UMEC, to FF/VI dual therapy via a single inhaler, administered once daily, improves lung function in patients with poorly controlled asthma on ICS/LABA. Additionally, this is the first single-inhaler triple therapy asthma study (to our …Francis wore the blood-stained cincture that Romero wore when he was killed in 1980. Pope Francis named seven new saints during Mass in St. Peter’s Square in the Vatican on Sunday ...Mar 23, 2022 · Results demonstrated a reduced risk of on/off-treatment death for patients who were maintained on a triple therapy compared to those who underwent step down to one of the dual therapies (FF/VI or UMEC/VI) (hazard … The second secret character in Final Fantasy VI is Gogo. Check the northeast corner of the World of Ruin, north of the shores of the Veldt, to find a triangular island. Here you'll run into giant worm enemies named Zone Eaters. Given a chance, they will suck your party members one by one into their mouths. Mar 27, 2015 · Undead is the one with clear disadvantages and some advantages. When selecting. the Rage of an Undead creature, the Rager will not die from Doom spells, Roulette spells cast by the enemy, the Condemned Lore and X-type Instant Death. coming from weapons. Instead, the Rager will be fully healed.The first step to setting up the iHome clock is selecting and adjusting the time zone. Press and hold the Time Zone button until the display begins to flash. Then, press the Select...Dec 11, 2023 · 2.vim删除^M 方式一：手动删除 我们前面通过方式一执行 :e ++ff=unix % 已经查看到了 ^M，符号，通过 i 编辑文本文件，删除 ^M 之后，:wq 保存并退出即可。 （注意：^M 看似两个字符，其实是一个字符，按一次删除按钮即可。 方式二：批量替换 如果 ...Nov 17, 2020 · In patients from Asia, the least squares (LS) mean change in trough FEV 1 from baseline at week 52 with FF/UMEC/VI (71 ml) was significantly greater than with FF/VI (− 28 ml; difference 100 ml [p < 0.001]) or UMEC/VI dual therapy (28 ml; difference 43 ml [p = 0.02]) and these differences between treatment groups were similar in magnitude to ...Apr 2, 1994 · 108种. 专题制作人：Mog、Meltina、bullfinch、 zhaoce 、红色战车 特别鸣谢：fldq. GBA版《最终幻想6A》完全汉化版终于完成，所有菜单字体、道具技能全面汉化，弥补了10年来FF6只有剧情汉化版的遗憾。. 本专题针亦对汉化版大幅更新，人物技能、魔法、武器、防具 ...Triple therapy with FF/UMEC/VI improved lung function in patients with moderate or severe uncontrolled asthma on ICS/LABA but did not lead to a reduction in moderate and/or severe exacerbations <https://bit.ly/38UnuRW> I. Ojanguren is a researcher supported by the Pla Estratègic de Recerca i Innovació en salut (PERIS) 2016–2020 (SLT008/18/ ...Nov 1, 2019 · The mean estimated 1-year on-treatment combined end point cost was highest for placebo and lowest for FF/VI ($4220 vs $3482, respectively). The reductions in cost versus placebo were significant for all active treatments (P <.0001). The likelihood of experiencing an on-treatment combined end point event was lower for patients treated with FF/VI ...Oct 24, 2022 · Patients and methods . IMPACT was a 52-week, randomized, double-blind, multicenter study comparing FF/UMEC/VI 100/62.5/25 µg with FF/VI 100/25 µg or UMEC/VI 62.5/25 µg in patients ≥40 years with symptomatic COPD and ≥1 moderate/severe exacerbation in the previous year.Dec 6, 2019 · Patients and methods. IMPACT was a 52-week, randomized, double-blind, multicenter study comparing FF/UMEC/VI 100/62.5/25 µg with FF/VI 100/25 µg or UMEC/VI 62.5/25 µg in patients ≥40 years with symptomatic COPD and ≥1 moderate/severe exacerbation in the previous year..